Jagadananda Ghosh Selected Research

Arachidonate 5-Lipoxygenase (5 Lipoxygenase)

1/2020	Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis.
1/2019	Inhibition of 5-lipoxygenase downregulates stemness and kills prostate cancer stem cells by triggering apoptosis via activation of c-Jun N-terminal kinase.
2/2015	Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells.
1/2015	MK591, a second generation leukotriene biosynthesis inhibitor, prevents invasion and induces apoptosis in the bone-invading C4-2B human prostate cancer cells: implications for the treatment of castration-resistant, bone-metastatic prostate cancer.
8/2013	OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
12/2012	Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt.
12/2011	Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon.
1/2006	Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.
3/2004	Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase.
7/2003	Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.

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Jagadananda Ghosh Research Topics

Disease

15	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 01/2002
6	Neoplasms (Cancer) 01/2022 - 03/2004
1	Neoplasm Metastasis (Metastasis) 01/2020

Drug/Important Bio-Agent (IBA)

11	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2020 - 01/2002
4	5-oxo-6,8,11,14-eicosatetraenoic acidIBA 08/2013 - 03/2004
4	Arachidonic Acid (Vitamin F)IBA 12/2012 - 03/2004
3	enzalutamideIBA 01/2022 - 11/2016
3	JNK Mitogen-Activated Protein KinasesIBA 01/2019 - 07/2003
3	AgarIBA 11/2016 - 01/2015
3	AndrogensIBA 11/2016 - 07/2003
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 11/2016
2	Small Interfering RNA (siRNA)IBA 01/2020 - 01/2006
2	wedelolactoneIBA 11/2016 - 12/2012
2	LeukotrienesIBA 01/2015 - 05/2010
2	GTP-Binding Proteins (G-Protein)IBA 08/2013 - 01/2006
2	SeleniumIBA 06/2010 - 03/2004
1	Keratin-8 (Keratin 8)IBA 01/2022
1	Androgen Antagonists (Antiandrogens)IBA 01/2022
1	Androgen Receptors (Androgen Receptor)IBA 01/2022
1	Phenobarbital (Luminal)FDA Link 01/2022
1	CaspasesIBA 01/2020
1	Oncogene Proteins (Oncogene Protein)IBA 11/2016
1	Messenger RNA (mRNA)IBA 11/2016
1	1- (6- ((3- methoxyestra- 1,3,5(10)- trien- 17- yl)amino)hexyl)- 1H- pyrrole- 2,5- dioneIBA 08/2013
1	Glycerol (Glycerine)FDA LinkGeneric 08/2013
1	Phospholipase C betaIBA 08/2013
1	coumestanIBA 12/2012
1	Caspase 3 (Caspase-3)IBA 12/2012
1	Proteins (Proteins, Gene)FDA Link 12/2012
1	Diazoxide (Hyperstat)FDA Link 12/2011
1	Peptides (Polypeptides)IBA 12/2011
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2011
1	Protein Kinase C-epsilonIBA 12/2011
1	Selenious Acid (Selenite)IBA 06/2010
1	MicroRNAs (MicroRNA)IBA 06/2010
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 05/2010
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 05/2010
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2010
1	Phosphatidylinositols (Phosphatidylinositol)IBA 05/2010
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2006
1	AcidsIBA 01/2006
1	Dietary Fats (Dietary Fat)IBA 03/2004
1	Fatty Acids (Saturated Fatty Acids)IBA 03/2004
1	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 03/2004
1	Arachidonate 12-Lipoxygenase (12 Lipoxygenase)IBA 03/2004
1	Lipoxygenase InhibitorsIBA 03/2004
1	EicosanoidsIBA 07/2003
1	Protein Kinases (Protein Kinase)IBA 07/2003
1	Death Domain ReceptorsIBA 01/2002

Therapy/Procedure

3	Therapeutics 01/2022 - 12/2012
2	Castration 01/2020 - 01/2015